Mechanosensitive ion channels in articular nociceptors drive mechanical allodynia in osteoarthritis
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چکیده
منابع مشابه
Mechanosensitive ion channels
Cell surface receptors are involved in numerous important biological processes including embryogenesis, tissue differentiation, and cellular homeostasis. Among them, mechanosensitive ion channels play an essential role in cellular functions of every cell including neurons, cardiomyocytes, and osteocytes. Here, we discuss types, roles, structures, and biophysical factors that affect the function...
متن کاملMechanosensitive ion channels
Mechanosensitive (MS) ion channels are to date the best characterized biological force-sensing systems. They present the best example of coupling protein conformations to the mechanics of the surrounding cell membrane. Studies of MS channels conducted over the last 28 years have from their serendipitous discovery and confusion about their artifactual nature to their molecular identification and...
متن کاملMechanosensitive Ion Channels in Cardiovascular Physiology
EC coupling is subjected to a mechanical feedback, which originates from physical force-sensing ion channels in the pericardium and elsewhere. Reviewed here are the most recent developments that greatly advanced our understanding of these mechanosensitive (MS) channels, including TRPs and K2p's. Patch clamp has continued to demonstrate the direct channel activation by membrane stretch. Crystall...
متن کاملGsMTx4: Mechanism of Inhibiting Mechanosensitive Ion Channels.
GsMTx4 is a spider venom peptide that inhibits cationic mechanosensitive channels (MSCs). It has six lysine residues that have been proposed to affect membrane binding. We synthesized six analogs with single lysine-to-glutamate substitutions and tested them against Piezo1 channels in outside-out patches and independently measured lipid binding. Four analogs had ∼20% lower efficacy than the wild...
متن کاملMechanosensitive ion channels as drug targets.
Mechanically sensitive ion channels (MSCs) are ubiquitous. They exist as two major types: those in specialized receptors that require fibrous proteins to transmit forces to the channel, and those in non-specialized tissues that respond to stress in the lipid bilayer. While few MSCs have been cloned, the existing structures show no sequence or structural homology--an example of convergent evolut...
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ژورنال
عنوان ژورنال: Osteoarthritis and Cartilage
سال: 2017
ISSN: 1063-4584
DOI: 10.1016/j.joca.2017.08.012